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DTSTAMP:20260522T150115Z
LOCATION:D165
DTSTART;TZID=America/Chicago:20181111T160000
DTEND;TZID=America/Chicago:20181111T161500
UID:submissions.supercomputing.org_SC18_sess147_ws_cafcw114@linklings.com
SUMMARY:Toward a Computational Simulation of Circulating Tumor Cell Transp
 ort in Vascular Geometries
DESCRIPTION:John Gounley (Duke University), Erik W. Draeger (Lawrence Live
 rmore National Laboratory), and Amanda Randles (Duke University)\n\nComput
 ational models can provide much needed insight into the mechanisms driving
  cancer cell trajectory. However, capabilities must be expanded to enable 
 simulations in larger sections of micro- and meso-vasculature and account 
 for the more complex fluid dynamic patterns that occur in patient-derived 
 vascular geometries. The increased size and complexity of these simulation
 s demands, in turn, the development of highly flexible and scalable comput
 ational frameworks. In this work, we extend the massively parallel hemodyn
 amics solver HARVEY to perform the necessary fluid-structure interaction f
 or CTC transport in high-resolution blood flow. We couple lattice Boltzman
 n and finite element methods, for the fluid and cells, respectively, with 
 the immersed boundary method for the fluid-structure interaction. Parallel
 ized with MPI, HARVEY is designed to handle the sparse and tortuous blood 
 vessels encountered in patient-derived vascular geometries while maintaini
 ng computational efficiency. HARVEY can be scaled to simulate vasculature 
 geometries containing hundreds of millions of blood cells, equivalent to b
 lood volumes on the order of tens of milliliters. In sum, the resulting fr
 amework has the potential to significantly improve the model fidelity of C
 TC simulations with respect to both the complexity and size of vascular ge
 ometries being considered.\n\nTag: Applications, Deep Learning, Exascale\n
 \nRegistration Category: Workshop Reg Pass\n\nSession Chairs: Thomas J. Ba
 rr (Nationwide Children's Hospital); Patricia Kovatch (Icahn School of Med
 icine at Mount Sinai); and Eric Stahlberg (MD Anderson Cancer Center, Univ
 ersity of Texas)\n\n
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